Creative Peptides Releases Custom PNA Probe Services for Specific Research Needs
Aug 8, 2022
New York City, New York Aug 8, 2022 (Issuewire.com) - Creative Peptides today released custom PNA probe services for clients' specific research needs. As a leading biomedical technology company engaged in PNA studies, the company can meet customers' requirements by providing a high level of quality control for the design and synthesis of each custom PNA probe project.
Peptide nucleic acids (PNAs) are unique oligonucleotide mimics with strong specific recognition ability and excellent chemical and biological stabilities. Experimentally, PNA used as a probe has high binding specificity, and a 15-mer PNA probe can replace a set of longer DNA probes. Moreover, PNA probes have a low background signal and favorable compatibility with a variety of reporter molecules and fluorescent dyes, including luciferin, rhodamine, cyanine, and Alexa dyes. As a result, these traits make PNA probes widely applied in disease diagnosis, cytogenetic analysis, histochemical in situ hybridization, as well as microbiological analysis.
Creative Peptides has been supplying various PNA probes such as CGA repeat probes, centromere probes, and telomere probes. In response to the growing need for PNA probes, the company also provides custom PNA probes based on its extensive experience in custom PNA synthesis and supreme probe design schemes, which can be self-reported and quencher-labeled.
Self-reported PNA probe
Self-reported PNA probes, or fluorescently labeled PNA probes, will not emit fluorescent or self-quench when there is no complementary target, which can effectively omit the separation and washing steps after probe hybridization.
Q-PNA PCR
A universal quencher-labeled PNA (Q-PNA) is hybridized at the 5' end of the primer labeled with Fluro, which will quench fluorescence upon annealing. During PCR, Q-PNA is replaced by the incorporation of primers via DNA polymerase into the amplicon, and the dye-labeled fluorescence is released when Q-PNA quenches the excessive primer.
So far, scientists at Creative Peptides can design and synthesize diverse PNA probes for research regarding genome, centromere, telomere, and infection tests. With years of exploration and expansion, the diversity of its PNA probes is expected to grow rapidly, thereby expanding the application ranges of PNAs.
About Creative Peptides
Peptide nucleic acid (PNA) research is one of Creative Peptides' major focuses. Its higher affinity, better discrimination than natural oligonucleotides, and its complete stability towards nucleases as well as proteases enable the use of PNA for many applications, including FISH probes for telomere, centromere, gene-specific probes, infection tests, anti-sense reagents, microarray probes, and miRNA inhibitors. However, PNA poses new challenges, e.g., poor aqueous solubility, the tendency to bind hydrophobic surfaces non-specifically, and the formation of aggregates in certain PNA molecules. Nevertheless, Creative Peptides can modify the PNA backbone & nucleobase and synthesize a variety of PNA products to meet clients' requirements.
Source :Creative Peptides
This article was originally published by IssueWire. Read the original article here.
Peso strengthens further to P62.585 vs. $1
The Philippine peso continued its upward momentum against the US dollar for the second straight day on Wednesday.
PSEi sinks to 5,700 level
Share prices on the Philippine Stock Exchange (PSE) closed in the red on Wednesday, with the local bourse barometer breaking below the 5,800 level, due lingering concerns about global geopolitics amidst the Middle East crisis.
Hong Kong unveils gold, bond and liquidity plans to drive next phase of yuan adoption
Bourse operator Hong Kong Exchanges and Clearing (HKEX) will launch yuan-denominated gold futures early next year, while the city’s de facto central bank plans to introduce more yuan products and platforms to support the diversification and digitalisation of the currency’s internationalisation, speakers at a banking summit said on Wednesday. “We have recently reactivated our gold contract in the US dollar. But in the future, perhaps sometime early next year, we will be coming up with a...
GCash IPO seen to boost PH capital market
Securities and Exchange Commission (SEC) Chairman Francis Lim said he is “fervently hoping” that the GCash IPO will help generate gains for the country"s capital market.
Marcos backs suspension of property tax hike - Palace exec
President Ferdinand “Bongbong” Marcos Jr. is supportive of the suspension of a property tax hike following the request of the Private Sector Advisory Council (PSAC), according to Malacañang on Wednesday.
Pinoy startup BossLabs AI sets sights on SE Asia expansion
Filipino software startup BossLabs AI is looking beyond its domestic presence, setting its sights on establishing a footprint in Southeast Asia with Malaysia, Indonesia, and Thailand as its initial targets.
Filinvest joins Pag-IBIG's Expanded 4PH as partner developer
Filinvest Land Inc. is joining Pag-IBIG Fund"s network of partner developers for its Expanded Pambansang Pabahay para sa Pilipino Program (4PH), giving Filipino workers greater access to quality homes at more affordable prices.
Physical moves by online financial firms unlikely to pump up property market: analysts
Digital financial service providers, including online brokerages and digital banks that used to trumpet their “zero-branch, fully online” models, have been opening physical stores across Hong Kong recently. Analysts described it as a strategic trend aimed at enhancing brand image and service quality to capture market share, but added that the impact on the city’s retail property market would be limited. Futu Securities International (Hong Kong) opened a new global headquarters at Pacific Place...
Chinese EV battery giant CATL starts trial production at Hungarian factory
Contemporary Amperex Technology Ltd (CATL) has cleared all regulatory hurdles for its mega factory in Hungary, a development that analysts expect will help the world’s largest producer of electric vehicle (EV) batteries extend its reach to international marques like BMW and Volkswagen. Production of battery cells at the €7.3 billion (US$8.35 billion) plant in Debrecen, the second-largest city in Hungary, began on Tuesday after it fulfilled all preconditions for a trial run, the company said. It...
GSIS expands benefits, financial options for pensioners
The Government Service Insurance System (GSIS) on Wednesday announced expanded benefits and financial assistance to government retirees, including higher funeral benefits, stronger survivorship protections, and solar energy loans for pensioners.
AI trade outlook brightens on falling oil and Meta’s Muse agent ahead of Xi-Trump meeting
The global artificial intelligence trade is staging a comeback, as a confluence of falling oil prices, Meta Platforms’ launch of a new agentic tool and anticipation surrounding the China-US leadership summit reignite investor interest in technology stocks. The Nasdaq-100 Index – where tech firms make up nearly 70 per cent of the 100 companies featured – hit an all-time high on Tuesday, surpassing the previous record set in June. In Asia, China’s chip-heavy Star Market 50 Index and South Korea’s...
Chinese maker of robot-vacuum sensors launches Hong Kong IPO, undeterred by US ban
Shenzhen Camsense Technologies, a maker of spatial sensors for robotic vacuum cleaners, launched a Hong Kong initial public offering (IPO) that aims to raise about HK$680 million (US$86.7 million), despite headwinds from Washington’s recent import ban on foreign-made vacuum robots. “The export and procurement for our existing client products remain normal, with potential disruption limited to new product development schedules,” Camsense co-founder Zhou Kun said about the ban’s impact. “We have...
_2025_12_16_15_53_06.jpg)
YOUR NEWS, OUR NETWORK.
Do you have Great News you want to tell the world?
Be it updates about your business or your community, you can make sure that it’s heard by submitting your story to our network reaching hundreds of news sites across 6 verticals.